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Methods in enzymology. v.400, Phase II conjugation enzymes and transport systems

Methods in enzymology. v.400, Phase II conjugation enzymes and transport systems

Packer, Lester

This volume on conjugation enzymes and transporters serves to bring together current methods and concepts in an interesting, important and rapidly developing field of cell and systems biology. It focuses on the so-called Phase II enzymes of drug metabolism (xenobiotics), which has important ramifications for endogenous metabolism and nutrition. Also included are aspects on Phase III, transport systems. This volume of Methods in Enzymology presents current knowledge and methodology on glucuronidation, sulfation, acetylation, and transport systems in this field of research. Together with the volumes on Quinones and Quinone Enzymes (volumes 378 and 382), and on Glutathione Transferases and gamma-Glutamyl Transpeptidases (volume 401), the state of knowledge on proteomics and metabolomics of many pathways of (waste) product elimination, enzyme protein induction and gene regulation and feedback control is provided. This volume will help stimulate future investigations and speed the advance of knowledge in systems biology. *A laboratory standard for more than 40 years*Over 400 volumes strong*Also available on ScienceDirect

Book. English.
Published Amsterdam; Boston: Elsevier, 2005

Available at O'Reilly Library.

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Statement of responsibility: edited by Helmut Sies, Lester Packer
ISBN: 0121828050, 9780121828059
Note: Includes indexes.
Physical Description: 695p, [30]p of plates : ill., some col. ; 24 cm.
Subject: Metabolic conjugation.; Xenobiotics Metabolism.; Metabolic detoxification.; Enzymology.
Added Entry: Phase II conjugation enzymes and transport systems


  1. UDP-glucuronosyltransferases: Gene structures of the UGT
  2. and UGT
  3. families; 2Identification and characterization of functional hepatocyte nuclear factor
  4. binding sites in UDP-Glucuronosytransferase genes
  5. Substrate Specificity of Human Hepatic UDP-Glucuronosyltransferaes
  6. UDP-glucuronosytransferase (UGT) 1A
  7. structural, functional and regulatory aspects
  8. The Role of Ah Receptor in Induction of Human UDP-glucuronosyltransferase 1A1
  9. Regulation of the human UGT1A
  10. gene by nuclear receptors CAR, PXR and GR
  11. Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases
  12. Structure of UDP-glucuronosyltransferases in membranes
  13. Human SULT1A genes: Cloning and activity assays of the SULT1A promoters
  14. Vitamin D Receptor Regulation of the Steroid/Bile Acid Sulfotransferase SULT2A1
  15. Screening and characterizing human NAT
  16. variant
  17. Inactivation of human arylamine N-acetyltransferase
  18. by hydrogen peroxide and peroxinitrite
  19. SULT and NAT in Mutagenicity Testing: Technical Aspects
  20. A comparative molecular field analysis (CoMFA) based approach to prediction of sulfotransferase catalytic specificity
  21. Glucuronidase deconjugation in inflammation
  22. Three-dimensional structures of sulfatases
  23. Estrogen sulfatase
  24. Analysis for localization of steroid sulfatase in human tissues
  25. Metabolism of Phytoestrogen Conjugates
  26. Coenzyme Q and phenolic conjugate metabolism
  27. Synthesis of bile acid CoA thioesters in the amino acid conjugation of bile acids
  28. Bile acid CoA: amino acid N-acyltransferase in the amino acid conjugation of bile acids
  29. Multidrug resistance protein 1-mediated export of glutathione and glutathione disulphide from brain astrocytes
  30. The genetics of ATP-binding cassette transporters
  31. Functional analysis of detergent-solubilized and membrane-reconstituted ABC Transporters
  32. Yeast ABC transporters - Cellular cleaning pumps
  33. High-speed screening of human ABC transporter function and genetic polymorphisms: New strategies in pharmacogenomics
  34. Coordinate transcriptional regulation of transport and metabolism
  35. Uptake and efflux transporters for anionic conjugates in human Hepatocytes
  36. Biliary canalicular transport systems: short-term regulation
  37. Inborn errors of biliary canalicular transport systems
  38. Epoxide Hydrolases - Structure, function, mechanism and assay
  39. Pregnane X receptor-mediated transcription
  40. Animal models of xenobiotic receptors in drug metabolism and diseases
  41. Cancer and molecular biomarkers of Phase